Characterization of the Internalization Dynamics of AGuIX®/AGuIX-Bi and Their Role on the Mechanism of Action of the Radiosensitization Effect
Nanoparticles made with elements like gadolinium (in AGuIX®) and bismuth (AGuIX-Bi) can act as contrast agents in medical imaging. They can also improve how radiation kills cancer cells. How they enter tumor cells and how close they get to the cells' nucleus determines their success. This project aims to understand exactly how these nanoparticles enter different cells within a tumor and the surrounding tissue. Advanced computer models will be used and laboratory experiments performed on cancer cells and mice to track the nanoparticles over time. Cutting-edge technology will analyze the individual characteristics of many different cells within the tumor and its environment after nanoparticle treatment. We may then pinpoint the best time to deliver radiation after treatment with nanoparticles to maximize their effect. We will gain further knowledge of the mechanisms underlying the radiosensitization effect. This research could lead to more precise and effective radiotherapy treatments for cancer patients.
