Optimizing Target Delineation and Motion Control in Cardiac Radioablation
We are developing advanced methods to more precisely treat ventricular tachycardia (VT) with radiation therapy. VT is a type of abnormal heart rhythm caused by disorganized electrical signals and can be life threatening. Stereotactic body radiotherapy (SBRT) is used to treat VT in patients who have not responded to standard treatments, but challenges preventing wider adoption remain, including reducing the amount of healthy tissue being irradiated and accounting for cardiac motion during treatment. We are working with electrophysiologists to develop software that integrates electrophysiology data, including electroanatomic mapping and voltage maps, with CT imaging to more accurately target the source of the VT. We are also evaluating the feasibility of using real-time electrocardiogram monitoring to synchronize treatment delivery with the diastolic phase of the cardiac cycle. Together, these innovations will help reduce treatment planning volumes, minimize side effects and toxicity, and potentially expand the number of patients who can benefit.
