Potentiating FLASH Radiotherapy Using SOD Mimetics in
Pancreatic Cancer
We are exploring a novel method to treat pancreatic cancer, which has one of the lowest rates of survival. Because the pancreas is located near many important organs, current treatments are often difficult or impossible. Radiation treatments for pancreatic cancer are limited by the sensitivity of the nearby bowel. FLASH radiation therapy (RT) is a new technology that delivers radiation much faster than current methods and has been shown to reduce radiation-induced damage in healthy tissues while still being effective against cancer. Using a pancreatic cancer model, we are testing whether FLASH RT and a class of drugs called superoxide dismutase (SOD) mimetics can shrink tumors and improve survival, while sparing the sensitive bowel. Our research aims to better understand how FLASH RT works and if SOD mimetics can amplify its effect. By combining these two emerging therapies, we hope to improve care and outcomes for people with pancreatic cancer.
